By Michael Baum, Craig Henderson
Every one quantity within the vintage Papers sequence provides as much as 2 hundred of crucial papers released in a specific strong point. The papers were conscientiously compiled, now not basically for his or her ancient value but additionally for his or her modern relevance. during this quantity, vintage Papers in Breast disorder, a group of specialists stocks their event in studying, diagnosing and treating breast ailment. The statement, consistently insightful and simple, levels from thought to perform, from actual to mental. for instance, experts talk about molecular biology and endocrinology in addition to the mental facets of the affliction and steps clinicians can take to control ache.
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Extra resources for Classic Papers in Breast Disease
This study does not prove this point, however, and Historical perspectives 27 provides no practical guidance to prospectively place a particular patient in one or the other of the two groups of patients defined by the study. Relevance Beware of all conclusions based on studies comparing groups that are defined by any criteria other than randomization. CHAPTER 2 Biostatistics JACK CUZICK Introduction A choice of papers that highlights pivotal biostatistical contributions to breast cancer is particularly difficult, not only because of the scope of ‘biostatistics’ but also its intrinsic interaction with the subject under study.
The method makes maximum use of complex family data from multiple loci. 3. This is an important first-line screening method for gene discovery. Classic papers in breast disease 50 Weaknesses 1. It is only really useful for highly penetrant genes. 2. It is typically only possible to localize genes to within about 10 base pairs, so considerable additional work is needed to find the gene. Relevance The multipoint linkage analysis method continues to be an important standard method in localizing highly penetrant genes that segregate with disease.
2) Baum M. The curability of breast cancer. British Medical Journal 1976; 1:439–442. e. unaffected by mastectomy) either because they have spread to distant organs before they can be detected or because they have little metastatic potential and limited, if any, lethality. Why it’s important This was the first of a number of thoughtful papers that challenged the paradigms that had become dogma over the previous century. By questioning the validity of these paradigms, these authors opened up the possibility that more limited surgery (or no surgery) might result in survival at least equal to that achieved with mastectomy and that the early use of systemic treatments, such as ovarian ablation and chemotherapy, would have a greater impact on survival than surgery.