By Johanna L'age-Stehr
International experts in Microbiology, Infectious illnesses, inner drugs, Cardiology Immunology, Pneumonolgy, Neurology and Epidemiology amassed to this workshop to debate and improve interdisciplinary wisdom at the attainable etiological position of Chlamydia pneumoniae, a frequent human breathing an infection, within the pathogenesis of persistent inflammatory ailments with significant public future health effect reminiscent of: - atherosclerosis, - heart problems, - grownup onset bronchial asthma bronchiale, - power obstructive pulmonary diseases,- reactive arthritis,- Morbus Alzheimer and - a number of Sclerosis. present deficits and pursuits in standardisation of diagnostic instruments, simple and utilized study, layout of epidemiological and tracking of treatment stories have been pointed out. a unique characteristic of this booklet is the great selection of state-of-the-art overview articles within the a variety of fields with many references and the enclosure of the controverse discussions to every article which gives the reader with a lifely photo at the function of Chlamydia pneumoniae in continual diseases.
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Additional resources for Chlamydia pneumoniae and Chronic Diseases: Proceedings of the State-of-the-Art Workshop held at the Robert Koch-Institut Berlin on 19 and 20 March 1999
By intranasal, intravenous and subcutaneous inoculations. Monkey models for C. pneumoniae infection Different monkey species, baboons as well as rhesus and cynomolgus monkeys, have been infected by using different challenge routes with C. pneumoniae, strain TWAR [4, 5]. The infected animals do not develop any clinical disease, both organisms can be recovered from the nasopharynx after inoculation. The infection persisted for a prolonged period and, interestingly, in cynomolgus monkeys the intranasally inoculated agent was demonstrated also in rectal swabs, pointing to a systemic spread .
I. Experimental infection of C. pneumoniae in mice and serum antibodies against TWAR by MFA. J Jap Assoc Infect Dis 64: 124-l31 Kaukoranta-Tolvanen SS, Laurila AL, Saikku P, Leinonen M, Liesirova L, Laitinen K (1993) Experimental infection of Chlamydia pneumoniae in mice. Microb Pathog 15: 293302 Yang ZP, Kuo CC, Grayston JT (1993) A mouse model of Chlamydia pneumoniae strain TWAR pneumonitis. Infect Immun 61: 2037-2040 Kaukoranta-Tolvanen SS, Laurila A, Saikku P, Leinonen M, Laitinen K (1995) Experimental Chlamydia pneumoniae infection in mice: Effect of reinfection and passive immunization.
Reactions with the reference serum are shown in lanes 11. With unboiled EBs (Figure 3A, lane 11) the pAbdOmc reacted with three bands of which the strongest is migrating as Omp4-5. The other bands may contain other GGAI proteins. In lanes 3, 6 and 8 microIF-negative sera were investigated. No bands were seen. The microIF-positive sera all reacted differently, but most sera recognized bands with migration patterns as seen for the reference serum (4 of 7 with the lower band, 5 of 7 with the intermediate band and 3 of 7 with the highest band).