Read e-book online Cell Therapy for Lung Disease PDF

By Julia Polak

Using stem cells to aid with lung regeneration and service is a singular treatment which may support section out the necessity for traditional surgical or pharmacological methods presently hired to regard ailments of the lung or different organs. the current ebook explores all avenues of this new kind of therapy, relocating quickly, yet extensive, from the elemental technological know-how of lung improvement, to the analyses of other stem telephone kinds to be had for regeneration and directly to the appliance of this data base in preliminary scientific trials. during this quantity a stellar team of researchers converge, from diversified angles, to assist in the direction of clarifying the fundamental mechanisms of lung fix. those variety from uncomplicated techniques of regeneration and lung improvement, the analyses of various cellphone forms that could be inquisitive about lung fix, to methods of making advanced lung constructions, together with synthetic and bioartificial lungs. The booklet deals an perception into fix mechanisms of the diseased lung, the function of particular lung niches and offers details on preliminary medical trials in addition to using stem cells as cars for gene remedy. creative technological features of assessing stem telephone engraftment of stem cellphone bioprocessing also are incorporated during this quantity.

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66. 67. 68. 69. 31 modeling and remodeling the same process? Am J Physiol Lung Cell Mol Physiol 283(3), L510–L517 (2002). A. Transdifferentiation of ciliated cells during repair of the respiratory epithelium. Am J Respir Cell Mol Biol 34(2), 151–157 (2006). J. New insights into airway mucous cell differentiation. Journal of Organ Dysfunction 2(1), 30–36 (2006). J. Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro. Am J Respir Cell Mol Biol 36(6), 661–668 (2007).

77. , and Hassan, M. Lung epithelial cells and type II pneumocytes of donor origin after allogeneic hematopoietic stem cell transplantation. Transplantation 78(1), 154–157 (2004). 78. , and Kreipe, H. Increased chimerism of bronchial and alveolar epithelium in human lung allografts undergoing chronic injury. Am J Pathol 162(5), 1487–1494 (2003). 79. , and Jaffe, A. Transbronchial biopsies provide longitudinal evidence for epithelial chimerism in children following sex mismatched lung transplantation.

2). qxd 14 2/12/2010 5:14 PM Page 14 D. J. Weiss Figure 2: Human b2-microglobulin and cystic fibrosis transmembrane conductance regulator (CFTR)-positive cells can be detected in NOD-SCID mice airways after systemic administration of cord blood mesenchymal stem cells (CB-MSCs). (A and B) NOD-SCID lung sections two weeks and one month after CB-MSC administration, respectively. (C and D) Corresponding higher power images of (A) and (B). Representative photomicrographs from one of four mice per experimental condition.

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