Download PDF by Jacques Derrida: Avances

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For example, important new information may be gained by testing mice in which the neurobiological substrates that mediate the effects of stimulant drugs have been altered. Implications for Drug Abuse Prevention The factors that influence drug use in humans can be divided into two broad categories of reward-related and impulsivity-related factors (de Wit and Richards 2004). The majority of drug abuse research using human and animal models has focused on reward-related factors, while impulsivity-related factors have received less experimental attention.

Following this logic, the mode of the RT distribution may be thought to reflect perceptual processing, decision making and motor speed, while the DevMod measure is thought to primarily reflect variability in responding due to momentary changes in attention, such as a lapse of attention. The use of attention tasks to measure impulsive behavior in animals is not novel. Premature responses that occur during the performance of the five choice serial RT task have been used as indicators of impulsive tendencies (Robbins 2007).

Other measures that produced significant differences between the two groups were the hold time and premature response measures. The C57 mice had significantly shorter hold time durations than the 129s mice and had more premature responses. These results are consistent with the analysis of the RT distributions above indicating that the C57 mice were not attending to the imperative stimulus. Premature responses are widely interpreted as being indicative of impulsive behavior in humans and rodents (Robbins 2007).

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