Adam Wanner, Robert A. Sandhaus's Alpha-1 Antitrypsin: Role in Health and Disease PDF

By Adam Wanner, Robert A. Sandhaus

This booklet bargains a entire assessment of alpha-1 antitrypsin deficiency, an inherited situation that results in lung ailment in adults and liver disorder in adults and kids and is linked to continual obstructive lung illness in adults. whereas it's a infrequent , the mechanisms underlying the scientific manifestations of this deficiency were mostly clarified. therapy, even if, is offered just for the lung ailment that arises from the situation, hence necessitating endured learn into new and substitute healing options. The ebook discusses the biology of alpha-1 antitrypsin, protein misfolding and polymerization, and prognosis and therapy of alpha-1 antitrypsin deficiency and its linked illnesses. It concludes with a dialogue of infrequent issues associated with alpha-1 antitrypsin deficiency and the function of healthcare corporations within the therapy of those ailments. Written for pulmonary clinicians and scientists, Alpha-1 Antitrypsin: function in overall healthiness and affliction is a invaluable source that sheds mild in this infrequent disease.

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Taggart C, Cervantes-Laurean D, Kim G, Mcelvaney NG, Wehr N, Moss J, Levine RL. Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity. J Biol Chem. 2000;275:27258–65. 69. Carp H, Miller F, Hoidal JR, Janoff A. Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity. PNAS. 1982;79:2041–5. 70. Beatty K, Bieth J, Travis J.

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