Download e-book for iPad: Airway Smooth Muscle in Asthma and COPD: Biology and by Kian Fan Chung

By Kian Fan Chung

During this publication, prime researchers in drugs and molecular pharmacology clarify the mobile mechanisms that keep watch over airway soft muscle. The capability through which those are disrupted in ailment, and the pharmacologic options through which they are transformed are mentioned and destiny healing interventions are identified. Aimed at experts in pulmonology, this quantity presents the clinician with the hottest details on one of many center physiological approaches in airway sickness, and gives insights into present and destiny ways to management. Authoritative replace on key mechanisms of airway constriction in bronchial asthma and COPDRelates most modern examine to bronchodilator therapyMulti-contributed textual content, co-coordinated through of the best gurus within the box.

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Extra resources for Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

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Antonissen, L. , Mitchell, R. , Kroeger, E. A. et al. (1979). Mechanical alterations of airway smooth muscle in a canine asthmatic model. J Appl Physiol 46, 681–687. Armour, C. , Black, J. , Berend, N. et al. (1984). The relationship between bronchial hyperresponsiveness to methacholine and airway smooth muscle structure and reactivity. Respir Physiol 58, 223–233. Bai, T. R. (1990). Abnormalities in airway smooth muscle in fatal asthma. Am Rev Respir Dis 141, 552–557. Bausch, A. , Boulbitch, A.

Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness? Am J Respir Cell Mol Biol 35, 55–64. An, S. S. and Hai, C. M. (1999). Mechanical strain modulates maximal phosphatidylinositol turnover in airway smooth muscle. Am J Physiol 277, L968–L974. An, S. S. and Hai, C. M. (2000). Mechanical signals and mechanosensitive modulation of intracellular [Ca2+ ] in smooth muscle. Am J Physiol 279, C1375–C1384. An, S. , Laudadio, R. , Lai, J. et al. (2002). Stiffness changes in cultured airway smooth muscle cells.

Panettieri, R. A. et al. (2003). Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. J Allergy Clin Immunol 111, S18–S34. Holloway, J. , Beghe, B. and Holgate, S. T. (1999). The genetic basis of atopic asthma. Clin Exp Allergy 29, 1023–1032. Homer, R. J. and Elias, J. A. (2000). Consequences of long-term inflammation. Airway remodeling. Clin Chest Med 21, 331–343. , Fabry, B. et al. (2003). Intracellular stress tomography reveals stress focusing and structural anisotropy in the cytoskeleton of living cells.

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