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By Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali (eds.)

​A entire assessment of the hot advancements in DNA fix learn that experience strength for translational purposes. The booklet explains intimately a number of the organic mechanisms in which melanoma cells can ward off anticancer remedy and boundaries its usefulness in sufferers. in addition they overview the influence of such novel inhibitors of DNA fix mechanisms as methylguanine-DNA-methyltransferase. additionally tested are inhibitors of different DNA fix enzymes corresponding to PARP and DNA-PK. The booklet captures-for either melanoma researchers and oncologists facing hallmark "relapse" or "drug resistance" phenomena on a regular basis-the many interesting new makes use of of DNA fix inhibitors, both on my own or together with anticancer therapies.​

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Nat Rev Mol Cell Biol 5(5):367–378 54. Yano K, Morotomi-Yano K, Wang SY et al (2008) Ku recruits XLF to DNA double-strand breaks. EMBO Rep 9(1):91–96 55. Wu PY, Frit P, Meesala S et al (2009) Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4. Mol Cell Biol 29(11):3163–3172 56. Drouet J, Delteil C, Lefrancois J et al (2005) DNA-dependent protein kinase and XRCC4DNA ligase IV mobilization in the cell in response to DNA double strand breaks. J Biol Chem 280(8):7060–7069 57.

Boone JJ, Bhosle J et al (2009) Involvement of the HER2 pathway in repair of DNA damage produced by chemotherapeutic agents. Mol Cancer Ther 8(11):3015–3023 160. Puzanov I, Lee W et al (2011) Phase I pharmacokinetic and pharmacodynamic study of SJG136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors. Clin Cancer Res 17(11):3794–3802 Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs 23 161. Middleton MR, Knox R et al (2010) Quinone oxidoreductase-2-mediated prodrug cancer therapy.

Li L, Keating MJ et al (1997) Fludarabine-mediated repair inhibition of cisplatin-induced DNA lesions in human chronic myelogenous leukemia-blast crisis K562 cells: induction of synergistic cytotoxicity independent of reversal of apoptosis resistance. Mol Pharmacol 52(5):798–806 154. Moufarij MA, Sampath D et al (2006) Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal. Blood 108(13):4187–4193 155.

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