By M. Cazzola, S. Sethi, F. Blasi, A. Anzueto
The reported variability within the prevalence and severity of power respiration ailments comparable to bronchial asthma and COPD, makes potent therapy tougher, and the social and monetary expenses of those illnesses the entire larger. Acute exacerbations are multi-factorial in foundation, and are identified to be associated with a couple of elements together with allergens, atmospheric toxins and infectious brokers. potent therapy calls for a equally complicated strategy that addresses all of the part reasons. this article brings jointly present wisdom of the epidemiology and pathophysiology of those episodes, and the most recent experimental versions through which researchers are looking for to enhance our figuring out in their occurrence and development. The ebook concludes with a assessment of the most recent rules on treatment for exacerbations. The authors evaluation the person efficacy of present remedies within the mild of this data and current new techniques for formulating powerful healing regimes.
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Additional resources for Acute Exacerbations in COPD
Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD. Thorax 2001; 56:36–41. Taylor D, Cripps A, Clancy R. A possible role for lysozyme in determining acute exacerbation in chronic bronchitis. Clin Exp Immunol 1995; 102:406–416. Arcavi L, Benowitz NL. Cigarette smoking and infection. Arch Intern Med 2004; 164:2206–2216. El Ahmer OR, Essery SD, Saadi AT et al. The effect of cigarette smoke on adherence of respiratory pathogens to buccal epithelial cells.
Am J Respir Crit Care Med 2007; 176:532–555. Wedzicha JA, Seemungal TAR. COPD exacerbations: defining their cause and prevention. Lancet 2007; 370:786–796. Rodriguez-Roisin R. Toward a consensus definition for COPD exacerbations. Chest 2000; 117:398S–401S. Celli BR, Barnes PJ. Exacerbations of chronic obstructive pulmonary disease. Eur Respir J 2007; 29:1224–1238. Fabbri L, Beghé B, Caramori G, Papi A, Saetta M. Similarities and discrepancies between exacerbations of asthma and chronic obstructive pulmonary disease.
43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 39 Hogg JC, Chu FSF, Tan WC et al. Survival after lung volume reduction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007; 176:454–459. Saetta M, Di Stefano A, Turato G et al. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157:822–826. Majo J, Ghezzo H, Cosio MG. Lymphocyte population and apoptosis in the lungs of smokers and their relationship with emphysema.